Title: Increased Activity in the Default Mode Network in Small Cell Lung Cancer Patients after Prophylactic Cranial Irradiation: A Resting State fMRI Analysis

Year of Publication: Oct - 2015
Page Numbers: 66-70
Authors: K Bromis , I S Karanasiou, M Koutsoupidou, G Matsopoulos, E Ventouras, N Uzunoglu, V Kouloulias, M Papathanasiou, N Kelekis, D Kelekis
Conference Name: The International Conference on Computer, Electronics, and Biomedical Engineering (ICCEBE2015)
- United Arab Emirates


Prophylactic cranial irradiation (PCI) is a treatment approach advised in certain types of cancer to increase life expectancy. However, neurocognitive impairments have been reported in cancer patients after being administered brain radiotherapy. The aim of the current study is to investigate potential alterations in brain functional activation of the default mode network (DMN) during resting state functional magnetic resonance imaging (fMRI) in small cell lung cancer (SCLC) patients after PCI treatment. Initial results show hyperactivity in several brain areas of the DMN including the precuneus and the superior parietal lobe in patients after PCI compared to their previous session (before PCI) as well as compared to controls. The findings of the current study are subject to further investigation using larger samples of patient participants.